HPV Vaccine. Woman should do it for Good!

March 1st, 2008 by alvita
Why Are HPV Vaccine Rates So Low?

It’s been hailed as one of the most effective ways to prevent cervical cancer, but millions of young women have yet to get immunized.

Newsweek Web Exclusive
Updated: 6:02 PM ET Feb 25, 2008

For Kari Lange, getting the human papillomavirus vaccine for her daughters, Erika, 16, and Darcy, 13, was a no-brainer. After all, the new vaccine is considered one of the most effective methods for preventing cervical cancer and genital warts. And the Lincolnshire, Ill., mom knew firsthand that even if the virus, which is transmitted through sexual contact, never progresses to cervical cancer, it is no picnic. She and her sister both contracted it when they were younger. "To me it wasn’t even about sex," says Lange about having her daughters vaccinated. "It was just healthy for the kids."

The Food and Drug Administration approved Merck’s human papillomavirus (or HPV) vaccine, Gardasil, in June 2006 for girls and women between the ages of 9 and 26. The U.S. Centers for Disease Control and Prevention, the American Academy of Pediatrics, and the American College of Obstetricians and Gynecologists all recommend it. But despite their efforts—and a national ad campaign by Merck urging viewers to be "one less" person with cervical cancer—only two out of every 10 women in the approved age group have gotten the vaccine so far.

Why isn’t everyone rushing to get immunized? In interviews with NEWSWEEK, health-care providers cited a variety of issues that may explain the low numbers: the high cost and inconvenience of the required three shots, a lack of awareness about HPV, the low number of regular physician visits among that age group, and parents’ unease over immunizing their kids against a disease contracted through sexual activity. If the United States wants to lower the number of women who get cervical cancer each year, health officials say they must overcome those barriers. But it won’t be easy.

Part of the problem is that—despite Merck’s multimillion-dollar ad campaign—many patients, and parents, are still not aware of the link between the virus and the cancer. More than one-quarter of American women between the ages of 14 and 59 are estimated to have HPV, according to a study published last year in the Journal of the American Medical Association. But one 2007 study found that only 40 percent of women in the United States had even heard of the virus. And only half of them knew that HPV is the primary cause of cervical cancer. A new survey from the National Association of Nurse Practitioners in Women’s Health found that more than 60 percent of women are unaware of any health problems associated with HPV. (In addition to abnormal cell growth, the virus can cause genital warts.)

The HPV vaccine doesn’t guarantee that a woman won’t get cervical cancer or warts, but it protects against viral types 16 and 18, which cause 70 percent of cervical cancer worldwide, and against types 6 and 11, which cause 90 percent of warts in both men and women. It’s still unknown when, or if, immunity will wane and whether women will need to get booster shots later in life. But levels of the antibody to HPV appear to stay high for at least five years. Even if another dose is needed, health officials feel confident that another dose of the HPV vaccine is safe. It’s not "biologically possible" to get HPV from the vaccine, which contains no live or killed virus and no viruslike particles, says the University of Michigan’s Dr. Amanda Dempsey. The most common side effect has been pain at the injection site, says John Iskander, acting director of the CDC’s immunization safety office.

But the vaccine is expensive: it typically costs $360 for three shots taken over six months. "There is a little bit of a sticker shock when they learn the cost," says Dr. James C. Turner, executive director of the department of student health at the University of Virginia and chair of the American College Health Association’s vaccine-preventable disease committee. More than 98 percent of privately insured Americans get at least some coverage for the HPV vaccine. But more than 46 million Americans are uninsured, including 27 percent of women ages 19 to 26 (who aren’t covered by the CDC’s Vaccines for Children program, since they’re not under 18).

Health officials say another issue is that the vaccine protects against a virus associated with sexual activity. That makes it tough for some parents to support early immunization. "This is a country that promotes abstinence-only sex ed," says Yale University gynecologist Dr. Mary Jane Minkin.

Even studies of physicians’ attitudes toward the vaccine have found that doctors are more likely to recommend the HPV shots for older teens, not tweens, because they’re "worried about parental response," says Dr. Jessica Kahn of Cincinnati Children’s Hospital Medical Center. "[Yet] to try to predict when your child is going to initiate sex and vaccinate right before then is a very risky proposition."

Ironically, one solution might be to make Gardasil available for even younger kids. Doctors say parents would then be less likely to think of it as a sex-related vaccine. That’s what happened with the hepatitis B vaccine, which is now given in three doses before babies are 18 months old. Earlier vaccinations also tend to have a higher compliance rate, since babies and young children typically visit their doctors more regularly than tweens and teens. The 2006 National Immunization Survey showed that 81.3 percent of 13-to-17-year-olds had received three doses of hep B.

For now, health officials are trying to target tweens with the concept of an "adolescent platform" of vaccinations that includes Gardasil. Ideally, preteens would get immunizations like the meningococcal conjugate vaccine (or MCV4), the tetanus, diphtheria, pertussis vaccine (or Tdap) and the HPV vaccine. The federal government’s Advisory Committee on Immunization Practices actually recommends that girls be immunized with all three at 11 or 12, and those aged 13 to 26 be given a "catch-up" vaccine.

Young women and girls may not be the only ones to get the vaccine in the future. Merck is also studying the vaccine in men, who in rare cases can get penile cancers, anal cancers and cancers of the head and neck from HPV. The drug company expects to submit data to the FDA on men later this year. And last month it submitted data to the FDA on trials conducted in women up to the age of 45.

Still, the most pressing goal is to increase the vaccination rates among tweens, so they’re immunized before they may be exposed to the virus. As awareness of the vaccine and its benefits spreads, there are encouraging signs that a growing number of parents are on board. "Cancer has touched my family," says Diane Simpson-Bundy, a suburban Chicago mom who plans to vaccinate her eight-year-old daughter in a couple of years. "If there’s an opportunity to prevent a particular kind of [cancer], I’m all for that."

That’s precisely the message health officials hope more parents will hear

Ageing makes the imagination wither

January 5th, 2008 by alvita

Old age does more than stealthily steal away our most cherished memories: it also seems to diminish our ability to imagine things.

This finding, detailed in the January issue of the journal Psychological Science 1, supports the ‘prospective brain’ hypothesis, the idea that imagining the future and remembering the past rely on the same neural machinery.

“One implication of this study is that imagining is quite closely related to, and dependent on, remembering, perhaps more so than we previously realized,” says Dan Schacter of Harvard University.

In the study, Schacter and his team asked groups of young and old participants, with average ages of 25 and 72, respectively, to recount a personal episode from their past or imagine a personal experience in their future in response to cue words.

Details in the participants’ narratives were categorized as either ‘internal’ or ‘external’. Internal memories are similar to scenes from a movie: they contain specific subjects and take place in particular settings and time periods. External memories consist mostly of general facts about the world, such as ‘the sky is blue’.

As expected, results showed that the past accounts of the older participants’ tales contained fewer, and less detailed, internal memories than those of the younger group. This deficit also extended to their future imaginings.

Imagine that

A young participant asked to imagine a personal scene in response to the cue word ‘engine’, for example, might envisage themselves driving in a red convertible along California’s Pacific Coast Highway one weekend over the summer. They might describe seagulls circling overhead, the feel of the wind mussing their hair, and the smell of the salt air as they round a particular corner.

In contrast, an older participant’s response to the same cue word was: "The scene is I’m just driving along, in the Saab, and … not worrying about high energy costs …"

It wasn’t that the older group had trouble speaking or spoke less, the researchers found. The older people scored normally on verbal tests, and they talked at length about non-personal external memories.

Brian Levine, a neuroscientist at the University of Toronto in Canada, is convinced that the data show a real decline in personal future imaginings. “I think that methodologically they have ruled out the other possible explanations,” Levine says. He adds that the findings are consistent with other studies examining future thinking in humans. "The more interesting question is ‘why?’," he says.

Scenic details

The researchers speculate that personal memories are particularly susceptible to ageing because they rely heavily on ‘relational processing’, the ability to mentally summon and join unique pieces of information, such as where and when an experience occurred. Stitching the particulars of a scene together — be it real or imagined — gets more difficult with age.

Over the past year, the prospective brain hypothesis has gained steady support among neuroscientists. An intriguing possibility raised by the hypothesis is that the primary role of human memory may not be to remember the past, but to imagine and prepare for the future.

“Once things in the past are finished, there’s nothing you can do about them,” Levine says.

cancer cells ‘feel’ much softer than normal cells

January 5th, 2008 by alvita

UCLA researchers discover cancer cells ‘feel’ much softer than normal cells

Nanotechnology method may help doctors detect and treat cancer more effectively

A multidisciplinary team of UCLA scientists was able to differentiate metastatic cancer cells from normal cells in patient samples using leading-edge nanotechnology that measures the cells’ softness.

The study, published Dec. 2 in the advance online edition of the journal Nature Nanotechnology, represents one of the first times researchers have been able to take living cells from cancer patients and apply nanotechnology to analyze them and determine which were cancerous and which were not. The nanoscience measurements may provide a potential new method for detecting cancer — especially in cells from body cavity fluids, where diagnosis using current methods is typically very challenging. The method also may aid in personalizing treatments for patients.

When cancer is becoming metastatic or is invading other organs, the diseased cells must travel throughout the body. Because these cells need to enter the bloodstream and maneuver through tight anatomical spaces, they are much more flexible, or softer, than normal cells. These spreading, invading cancer cells can cause a buildup of fluids in body cavities such as the chest and abdomen. But fluid buildup in patients does not always mean cancer cells are present. If the fluid could be quickly and accurately tested for the presence of cancer, oncologists could make better decisions about how aggressive a treatment should be administered or if any treatment is necessary at all.

In this study, researchers collected fluid from the chest cavities of patients with lung, breast and pancreatic cancers — a relatively non-invasive procedure. One problem with diagnosing metastatic disease in this setting is that cancer cells and normal cells in body cavity fluids look very similar under an optical microscope, said Jianyu Rao, a researcher at UCLA’s Jonsson Cancer Center and one of the study’s senior authors. Conventional diagnostic methods fail to detect about 30 percent of cases in which cancer cells are present in the fluid.

"We detect cancer cells typically by looking at them under a microscope after the cells are fixed and stained with chemicals, which is really an antiquated method," said Rao, who is also an associate professor of pathology and laboratory medicine at the David Geffen School of Medicine at UCLA. "Usually, the cancer cells have larger nuclei and other subtle features. However, the normal cells from body cavity fluids can look almost identical to cancer cells under an optical microscope. While staining for tumor protein markers could increase diagnostic accuracy, what we were missing was a way to determine if cancer cells have different mechanical properties than normal cells."

Employing one of the most valuable tools in the nanotechnology arsenal, the research team used an atomic force microscope (AFM) to measure cell softness. Since the cells being analyzed were less than half the diameter of a human hair, researchers needed a very precise and delicate instrument to measure resistance in the cell membrane, said chemistry and biochemistry professor James Gimzewski, a member of UCLA’s California NanoSystems Institute and also one of the study’s senior authors.

"We had to measure the softness of the cell without bursting it," Gimzewski said. "Otherwise, it’s like trying to measure the softness of a tomato using a hammer."

The AFM uses a minute, sharp tip on a spring to push against the cell surface and determine the degree of softness. Think of it as an extension of a doctor’s hands performing a physical examination to determine disease, Gimzewski said.

"You look at two tomatoes in the supermarket and both are red. One is rotten, but it looks normal," Gimzewski said. "If you pick up the tomatoes and feel them, it’s easy to figure out which one is rotten. We’re doing the same thing. We’re poking and quantitatively measuring the softness of the cells."

After probing a cell, the AFM assigns a value that represents how soft a cell is based on the resistance encountered. What the team found was that the cancer cells were much softer than the normal cells and that the cancer cells were similarly soft with very little variation in gradation. The normal, healthy cells from the same specimen were much stiffer; in fact, the softness values assigned to each group did not overlap at all, making diagnosis using this nanomechanical measurement easier and more accurate.

"It was fascinating to find such striking characteristics between the metastatic cancer cells and normal cells," said Sarah Cross, a UCLA graduate student in chemistry and biochemistry and a study author. "The metastatic cancer cells were extremely soft and easily distinguishable from the normal cells despite similarities in appearance. And we’re looking at live cells taken from human patients, so that makes this is a unique finding."

Calvin Quate of Stanford University, the co-inventor of the atomic force microscope, said the UCLA study breaks new ground.

"This manuscript is the first that directly shows a relationship between the nanomechanical properties and physiological function in clinical samples from patients with suspected cancer," said Quate, recipient of the 1992 National Medal of Science.

National breast cancer expert Susan Love said the study findings "open a new era for function-based tumor cell diagnostics."

"With these findings, it is foreseeable that a combined biochemical, biophysical and morphological analysis for analyzing human cytological specimens using the AFM may be finally realized," said Love, president and medical director of the Susan Love Research Foundation and a clinical professor of surgery at UCLA.

Researchers next will explore whether the nanomechanical analysis can be used to personalize cancer treatment based on the characteristics of a patient’s cancer cells. There are standard chemotherapy drugs that are used to treat metastatic cancer, Rao said, but response varies from patient to patient. If researchers could test the cancer cells beforehand, they could potentially apply therapies that would make the cells stiffer, making it more difficult for the diseased cells to spread through the body.

Curvy women may be a clever bet

November 15th, 2007 by alvita

Women with curvy figures are likely to be brighter than waif-like counterparts and may well produce more intelligent offspring, a US study suggests.

Researchers studied 16,000 women and girls and found the more voluptuous performed better on cognitive tests - as did their children.

The bigger the difference between a woman’s waist and hips the better.

Researchers writing in Evolution and Human Behaviour speculated this was to do with fatty acids found on the hips.

In this area, the fat is likely to be the much touted Omega-3, which could improve the woman’s own mental abilities as well as those of her child during pregnancy.

Men respond to the double enticement of both an intelligent partner and an intelligent child, the researchers at the Universities of Pittsburgh and California said.

The findings appear to be borne out in the educational attainments of at least one of the UK’s most famous curvaceous women, Nigella Lawson, who graduated from Oxford.

But experts are not convinced by the findings.

"On the fatty deposits being related to intelligence front, it’s very hard to detangle that from other factors, such as social class, for instance, or diet," said Martin Tovee of Newcastle University.

"And much as we logically like the idea that men are interested in the waist to hip ratio, it actually features relatively low down the list of feature males look for in a potential partner."

Onions ‘cut heart disease risk’

November 5th, 2007 by alvita

Eating a meal rich in compounds called flavonoids reduces some early signs of heart disease, research shows.

An Institute of Food Research team focused on one of the compounds, quercetin, which is found in tea, onions, apples and red wine.

The Atherosclerosis study examined the effect of the compounds produced after quercetin is broken down by the body.

They were shown to help prevent the chronic inflammation which can lead to thickening of the arteries.

The effect is more subtle than laboratory experiments using the parent compound
Dr Paul Kroon
Institute of Food Research

Previous research has shown quercetin is metabolised very quickly by the intestine and liver and is not actually found in human blood.

So instead the researchers concentrated on the compounds that enter the bloodstream after quercetin is ingested, absorbed and metabolised.

The compounds were used - in concentrations similar to those that would be produced following digestion - to treat cells taken from the lining of the blood vessels.

Lower dose, bigger impact

Lead researcher Dr Paul Kroon said: "We tested compounds that are actually found in the blood, rather than the flavonoid in food before it is eaten, as only these compounds will actually come into contact with human tissues and have an effect on arterial health.

"The effect is more subtle than laboratory experiments using the parent compound.

"But the metabolites still have an effect on the cells lining the blood vessels."

The research found that, in the case of one inflammatory process, a lower dose of the compounds - achievable by eating 100g to 200g of onions - actually had a bigger impact.

Bridget Aisbitt, a nutrition scientist at the British Nutrition Foundation, said: "Inflammation is an important process in the furring up of arteries that can lead to heart disease and stroke and this study gives us clues as to why a diet rich in fruit and vegetables appears to reduce the risk of these conditions.

"In the UK we are only consuming about two portions of fruit and vegetables per day on average, so this study underlines the importance of getting your five a day to stay healthy throughout life."

Starchy diet ‘may damage liver’

September 22nd, 2007 by alvita

A diet rich in potatoes, white bread and white rice may be contributing to a "silent epidemic" of a dangerous liver condition.

"High-glycaemic" foods - rapidly digested by the body - could be causing "fatty liver", increasing the risk of serious illness.

Boston-based researchers, writing in the journal Obesity, found mice fed starchy foods developed the disease.

Those fed a similar quantity of other foods did not.

One obesity expert said fatty liver in today’s children was "a tragedy of the future".

GLYCAEMIC INDEX
High GI foods:
Mashed potato
White bread
Chips
Some breakfast cereals (eg Cornflakes, Rice Krispies, Coco Pops)
Steamed white rice
Moderate GI foods:
Muesli (non-toasted)
Boiled potatoes
Pitta bread
Basmati rice
Honey
Wholemeal bread
Low GI foods:
Roasted salted peanuts
Rye and granary bread
Whole and skimmed milk
Spaghetti
Boiled carrots
Baked beans

Fatty liver is exactly as it sounds - a build-up over time of fat deposits around the organ.

At the time, no ill-effects are felt, but it has been linked with a higher risk of potentially fatal liver failure later in life.

The study, carried out at Boston Children’s Hospital, looked at the effect of diets with precisely the same calorific content, but very different ingredients when measured using the glycaemic index (GI).

This is a measure of how quickly the energy in the food is absorbed by the body, producing a rise in blood sugar levels - high GI foods lead to sharper rises in blood sugar, and similar rises in insulin levels, as the body releases the chemical in response.

High GI foods include many breakfast cereals and processed foods such as white bread and white rice.

Low GI foods include unprocessed fruit, nuts, pulses and grains, including rye or granary bread, spaghetti, apples and oranges.

Silent and deadly

After six months on the diet, the mice weighed the same, but those on the high GI diet had twice the normal amount of fat in their bodies, blood and livers.

Fatty liver is going to be one of the tragedies of the future unless we do something about it
Tam Fry, National Obesity Forum

The researchers say that because the processed carbohydrates are absorbed so quickly, they trigger the release of more of the chemical insulin, which tells the body to lay down more fat.

Dr David Ludwig, who led the research, said that the results would also apply to humans, and even children, in whom fatty liver is becoming far more common.

Between a quarter and half of all overweight American children are thought to have the condition, he said.

"This is a silent but dangerous epidemic," he said.

"Just as type 2 diabetes exploded into our consciousness in the 1990s, so we think fatty liver will in the coming decade."

Insulin resistance

Tam Fry, National Obesity Forum board member and chairman of the Child Growth Foundation, said it was clear that eating a diet rich in high-glycaemic food led to increased fat.

He said: "Fatty liver is going to be one of the tragedies of the future unless we do something about it."

Azmina Govindja, a dietician and spokesman for the British Dietetic Association, said that the biggest threat from a diet rich in high-glycaemic food was development of insulin resistance - the first sign of type 2 diabetes.

She said: "There is a place for high-glycaemic carbohydrates in moderation as part of a balanced diet, but there’s good research that eating too much can increase the risk of insulin resistance - and this can lead to serious health problems.

"However, this study is interesting, as there is other evidence that people who eat a diet rich in high-glycaemic food are more likely to have more body fat."

Why kissing means more to women

September 4th, 2007 by alvita

If a picture is worth a 1,000 words, so may be a kiss - or certainly to a woman anyway, researchers say.

A State University of New York team quizzed over 1,000 students, finding women place a big emphasis on kissing.

They use kissing as a way of assessing the recipient as a potential partner, and later to maintain intimacy and to check the status of a relationship.

But men placed less importance on it, using it to increase the likelihood of sex, Evolutionary Psychology reported.

The questionnaires revealed men were less discriminating when it came to deciding who to kiss or who to have sex with.

While both sexes participate in the adaptive benefits of kissing, we found sex differences when considering the pursuit of short-versus long-term mating strategies
Dr Gordon Gallup, lead researcher

They were more willing to have sex with someone without kissing, to have sex with someone they are not attracted to and agree to have sex with someone they considered to be a bad kisser.

But kissing was more important as a bonding mechanism to women.

In long-term relationships females not only rate kissing as more important than men, but they indicated that kissing was important throughout a relationship.

Meanwhile, men placed less importance on kissing as the relationship progresses.

There was also a difference in the sort of kisses the two sexes preferred, with men liking wet, tongue kisses.

Lead researcher Dr Gordon Gallup said kissing had developed over time to become an essential part of the courtship process.

But he added: "While both sexes participate in the adaptive benefits of kissing, we found sex differences when considering the pursuit of short- versus long-term mating strategies."

Dr Glenn Wilson, an expert in relationships at London’s Institute of Psychiatry, said: "Kissing is used by everyone as a bonding and testing mechanism.

"But the fact is women are more discriminatory than men. Men can just go out and spread their seed, but women have to take more responsibility because of the consequences and so they are likely to want to test more."

Researcher Discovers Anti-Viral Properties of Cinnamon, With a Hint From the Bible

August 21st, 2007 by alvita

Professor Michael Ovadia, a spiritual scientist from Tel Aviv University, has signed a research and license deal on his patent-pending cinnamon extract, which has potent anti-viral properties.

He received the hunch for his breakthrough research while listening to a reading from the Old Testament. The passage explains how the High Priests would prepare a holy oil, which they applied to their bodies before making a ritual animal sacrifice. Ovadia had a hunch that this oil, which was prepared with cinnamon and other spices, was in fact a means of preventing the spread of infection to the people.

However, the cinnamon extract Ovadia has created is not equivalent to eating regular cinnamon. It is extracted from a special variety of cinnamon — coumarin and cinnamon aldehyde, which are byproducts of cinnamon “juice.”

Dr. Ovadia’s cinnamon extract has several potential uses, including:

  • Disinfecting the air against the Avian flu in airports
  • Being used as an alternative to the flu vaccine
  • Immunizing chicken embryos against the Newcastle disease virus
  • Using it in air conditioning systems in hospitals to prevent the spread of infectious diseases

Studies on the Avian Flu H9, the Sendai virus, HIV and Herpes Simplex 1 have also achieved positive results. The extract has been found to both neutralize viruses, as well as immunize against them.

Why girls ‘really do prefer pink’

August 21st, 2007 by alvita

A little girl’s love of all things pink may not be entirely due to marketing by clothes and toy firms say researchers.

A University of Newcastle study found that women naturally opted for redder shades when given a choice.

Writing in the journal Current Biology, experts say it may have helped women gather ripe fruit, or pick healthy mates.

Most earlier studies into colour suggest a universal liking for blue, regardless of sex.

This is one of the few studies that have tried to spot differences between the likes of males and females.

The Newcastle team, led by Dr Anya Hurlbert, tested more than 200 men and women in their 20s, asking them to choose between colours on the computer screen.

Women were far more likely to choose blue shades with more red mixed in, and more likely to reject more green and yellow hues.

Nature or nurture?

One of the problems facing the researchers was to work out if this reaction is the product of years of British "blue for a boy, pink for a girl" culture.

To do this, the group tested were a mixture of white British and Chinese volunteers.

Evolution may have driven females to prefer reddish colours - reddish fruits, healthy, reddish faces
Dr Anya Hurlbert, Newcastle University

While the Chinese volunteers, male and female, also tended to favour red shades, not surprisingly since red is a "lucky" colour in China, the difference between men and women persisted.

According to the researchers, this strengthened the idea that the preferences might be based in biology, rather than culture.

Dr Hurlbert said: "Evolution may have driven females to prefer reddish colours - reddish fruits, healthy, reddish faces.

"Culture may exploit and compound this natural female preference."

Depression and colour

Yazhu Ling, another researcher working on the project, said that work was planned in younger children to confirm the finding.

She said that she expected other projects to investigate links between colour preference and weight, and depression.

No clear explanation exists as to why all humans might also have an underlying liking for blue.

Dr Hurlbert speculated: "Going back to our ’savannah’ days, we would have a natural preference for a clear blue sky, because it signalled good weather.

"Clear blue also signals a good water source."

Darker fruits could fight cancer

August 21st, 2007 by alvita

The compounds which give certain fruit and vegetables their dark colour may contain powerful cancer fighting properties, US research suggests.

Studies on rats and human cells found anthocyanins - which colour red, purple and blue fruits - notably slowed the growth of colon cancer cells.

The more exotic the plant the better: purplecorn and bilberry were found to be much more potent than the radish.

The research was presented at a meeting of the American Chemical Society.

In some experiments, the researchers from Ohio State University saw cancer growth not just slowed, but as many as 20% of the cells killed.

For instance, anthocyanin pigments obtained from black carrots and radishes slowed the growth of cancer cells by between 50 to 80%.

But compounds from chokeberries for instance killed up to a fifth of existing cells, without impacting upon healthy ones.

Working it out

The researchers say their findings bring the scientific community closer to understanding what it is that gives fruit and vegetable their much touted cancer-fighting properties.

"These foods contain many compounds, and we’re just starting to figure out what they are and which ones provide the most health benefits," said Monica Giusti, the lead author of the study.

She suggested that the results from this particular study suggested that anthocyanin may be of particular use in fighting gastrointestinal cancers.

Very little of the substance is absorbed by the bloodstream, but it may be absorbed in the gastrointestinal tract as it passes through, she said.

However, the researchers stopped short of recommending one particular fruit and vegetable over another, stressing that more research was needed into how these compounds worked.

Henry Scowcroft, senior information officer at Cancer Research UK, said: "Although at an early stage, this research helps us understand exactly how the substances in fruit and veg protect us from bowel cancer.

"Isolating these substances - and tweaking them so that they’re even more potent - could allow scientists to develop new drugs to treat the disease.

"In the future, it could lead to the development of drugs that help prevent bowel cancer in people at high risk."